Clostridium perfringens type A–E toxin plasmids
نویسندگان
چکیده
منابع مشابه
Toxin plasmids of Clostridium perfringens.
In both humans and animals, Clostridium perfringens is an important cause of histotoxic infections and diseases originating in the intestines, such as enteritis and enterotoxemia. The virulence of this Gram-positive, anaerobic bacterium is heavily dependent upon its prolific toxin-producing ability. Many of the ∼16 toxins produced by C. perfringens are encoded by large plasmids that range in si...
متن کاملEpsilon-toxin plasmids of Clostridium perfringens type D are conjugative.
Isolates of Clostridium perfringens type D produce the potent epsilon-toxin (a CDC/U.S. Department of Agriculture overlap class B select agent) and are responsible for several economically significant enterotoxemias of domestic livestock. It is well established that the epsilon-toxin structural gene, etx, occurs on large plasmids. We show here that at least two of these plasmids are conjugative...
متن کاملCharacterization of toxin plasmids in Clostridium perfringens type C isolates.
Clostridium perfringens type C isolates cause enteritis necroticans in humans or necrotizing enteritis and enterotoxemia in domestic animals. Type C isolates always produce alpha toxin and beta toxin but often produce additional toxins, e.g., beta2 toxin or enterotoxin. Since plasmid carriage of toxin-encoding genes has not been systematically investigated for type C isolates, the current study...
متن کاملComparison of virulence plasmids among Clostridium perfringens type E isolates.
Clostridium perfringens type E isolates produce iota-toxin, which is encoded by iap and ibp genes. Using Southern blot analyses, the current study identified iap/ibp plasmids of approximately 97 or approximately 135 kb among eight type E isolates. For most of these isolates, their iap/ibp plasmid also encoded urease and lambda-toxin. However, the beta2-toxin gene, if present, was on a different...
متن کاملGlycosylating Toxin of Clostridium perfringens
Clostridium perfringens type C strains that produce various toxins cause hemorrhagic noxious ulceration or mucousal necrosis of the small intestine in humans, pigs, cattle and chickens (Sakurai et al. 1997, Sakurai and Nagahama 2006). In humans, the bacteria cause necrotic enteritis, which is termed “pig-bel” (Sakurai and Nagahama 2006). C. perfringens has been classified into five types, A to ...
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ژورنال
عنوان ژورنال: Research in Microbiology
سال: 2015
ISSN: 0923-2508
DOI: 10.1016/j.resmic.2014.09.004